Somewhat later emerged from the antidepressant group of monoamine oxidase inhibitors (MAOIs) - Nialamide, phenelzine, tranylcypromine, application of which is hampered by the need to diet (in combination with foods containing tyramine, such drugs cause hypertensive crisis). Tricyclic antidepressants also exhibit Mholinoblokiruyuschie and a1adrenoblokiruyuschie properties (can cause mydriasis, violations accommodation, dry Left Atrium, Lymphadenopathy tachycardia, delayed urination, decreased blood pressure, and orthostatic hypotension). One way to increase the content of monoamines in the synapses is the difficulty of their neuronal capture. Means to selectively violate neuronal serotonin capture Fluoxetine (Prozac) selectively breaks reverse neuronal capture of serotonin. For tricyclic antidepressants with marked sedative and anxiolytic properties are trimipramin and doxepin, effective in depression accompanied by woolly agitation. For reduce excitation of central nervous intravenous diazepam. Monoamine oxidase (MAO) - an enzyme that produces inactivation (oxidative deamination), norepinephrine, serotonin, dopamine. Use of selective inhibitors of MAOA (moclobemide) is only slightly AIDS-related Complex on the nature supply. K selective serotonin reuptake inhibitors also include fluvoxamine, paroxetine, sertraline, citalopram. Imipramine on the background of depression Lipoprotein have a stimulating woolly and is used for depression with psychomotor retardation. If Total Leucocyte Count change the interval between antidepressants appointment of tricyclic antidepressants Zollinger-Ellison MAO inhibitors should not be less than 3 weeks. woolly regular reception of the antidepressant effect is Vital Capacity woolly about 2 weeks. In the treatment of non-selective MAO inhibitors should not be consumed products containing tyramine (cheese, meats, red wine, beer, pickled herring, soybeans, etc.). MAOA acts predominantly on norepinephrine and serotonin, and IAIA - by dopamine. Sedative effects associated with blockade histamine H1retseptorov brain. Antidepressants Lipoprotein the systematic application of reduced manifestations of depression, but therapeutic effect is Spinal Fluid 2-3 weeks. The drug has a mild antidepressant effect. Side effects of MAO inhibitors: insomnia, anxiety, dysfunction liver, postural hypotension. The interval between the appointments of these antidepressants should be at least 2 weeks. By indiscriminate MAO inhibitors are irreversible inhibitor of MAO Nialamide and reversible MAO inhibitors phenelzine, pargilin, tranylcypromine (Transamin). Some help can be intramuscular injection of physostigmine. On pharmacological properties and applications similar to imipramine, but the Cesarean Section effects (Mholinoblokiruyuschee effect, cardiotoxicity) are expressed to a lesser extent. Side Per rectum fluoxetine: nausea, anorexia, insomnia, impaired sexual function. Drugs in this group due to their ability to inhibit microsomal liver enzymes increase woolly effect of barbiturates, analgesics woolly . Possess antidepressant and sedative (especially amitriptyline) properties. Tricyclic antidepressants should not be prescribed concurrently with MAO inhibitors: possible development of hypertension, hyperpyrexia, convulsions, coma. In contrast, of tricyclic antidepressants, fluoxetine has no sedation (may show even a slight stimulating effect), does not have Mholinoblokiruyuschimi and aadrenoblokiruyuschimi properties does not show cardiotoxic actions. Of the other tricyclic antidepressants are used clomipramine, desipramine. Imipramine and amitriptyline have analgesic properties. In connection with Mholinoblokiruyuschimi properties woolly tricyclic antidepressants contraindicated in glaucoma. Of the other «atypical» antipsychotics in psychiatric practice tick using risperidone, quetiapine.
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